role of erbb2 in signal transduction and oncology
| PAG Title | role of erbb2 in signal transduction and oncology |
| PAG ID | WAG000410 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with the molecular weight of 185 KDa. Unlike other members of EGFR family, no ligand for Her2 has been found and it usually associates with members of ERBB1 family to form functiol heterodimers. It has been shown that it can form dimers with ERBB (EGFR), ERBB3 and ERBB4 as well as gp130 subunits of IL-6 receptor. In at least some cell types, the association between gp130 and HRBB2 is essential for HRBB2-ERBB3 phosphorylation and subsequent MAP kise sigling. Although ERBB1 can form homodimers, the sigling for ERBB1 is usually transient and the receptor undergoes interlization after ligand binding and activation. EGFR-HER2 complex increases the sigling capacity of EGFR by increasing the ligand affinity as well as the recycling of the heterodimer. Of all the ERBB heterodimers, ERBB2-ERBB3 heterodimers perhaps elicit the strongest sigl. Removing ERBB3 from the cell has a drastic effect on ERBB2 mediated sigling and downstream effectors. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 4,739 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG000410 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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